Escape from Paradise, – A Best Selling Book!

The book’s sensational reviews!

It took me two and a half evenings to complete your un-put-downable book…it is a unique contribution to the appreciation of a life in Singapore. Thank you for having written it.” C. V. Devan Nair, former President of Singapore.

Bought the book from Select this weekend and can’t put it down! It’s a great read! And so nostalgic for me—the good old days! Glen Goei, writer and director of the Miramax film That’s the Way I Like It and who played the title role opposite Anthony Hopkins in the London production of M. Butterfly. Mr. Goei’s latest film is The Blue Mansion – Click for the trailer!

It is a remarkable story and so full of intrigue that it reads at times like fiction.Jonathan Burnham, Editor in Chief & President, Talk Miramax Books.

“It’s quite a story The legendary Alice Mayhew, Vice-President & Editorial Director, Simon & Schuster.

This book out-Dallas, Dallas. No one has written so well of the other side of paradise,Francis T. Seow, former Solicitor General of Singapore

ThunderBall Films is successfully putting together the movie production of Escape from Paradise and has received a new LOI (Letter of Intent) from actress Bai Ling who starred with Richard Gere in the film Red Cross.

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Escape from Paradise – the Promotional Trailer

Mary Bancroft – Master Spy

“I can’t understand what the f–k you are saying.” The voice came from an elderly lady in the back row of my computer class. It was from Mary Bancroft, a part owner of The Wall Street Journal. She is the author of Autobiography of a Spy and was the woman behind the plot to kill Hitler, the lover of CIA chief, Allen Dulles, the lady who invited me to dinner to meet Woody Allen and, yes, Mary Bancroft was my computer student.

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Copyright © 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020 John Harding

Americans suffer brain damage from marijuana

Researchers from Northwestern University, Harvard Medical School, and Massachusetts General Hospital used MRI scans to compare the brains of 20 18- to 25-year-olds who smoked at least once a week to those of 20 individuals who had little or no history of using the drug. Though the low to moderate marijuana users were not addicted to the drug, imaging data showed that their brain anatomy had changed irreversibly.

The nucleus accumbens, a part of the brain linked to reward processing, was larger and had changed shape in casual smokers compared to non-users. The researchers also found that the amygdala, which helps to regulate emotions, had also changed in shape and density in those who smoked the drug.

“While I don’t think anyone has directly contrasted recreational with dependent users, it is pretty clear from our data that the more you use, the more the brain is impacted,” said Anne Blood, Ph.D., who leads the Laboratory for Mood and Movement Disorders at Massachusetts General Hospital.

“This study raises a strong challenge to the idea that casual marijuana use isn’t associated with bad consequences,” added Dr. Hans Breiter, a professor of psychiatry and behavioral sciences at Northwestern University, who was also involved with the study.

Blood said that any brain changes have the potential to cause behavioral and neurological changes as well. The parts of the brain where they detected structural differences are “powerhouses of function.”

“These are not brain regions that you want to alter,” she said, calling for more studies that target recreational marijuana users. “There is no doubt that we will find these structural changes have some impact on these individuals’ neurological or psychiatric and behavioral function.”

So much for Obama’s “American Exceptionalism.”

Cannabis Use Is Quantitatively Associated with Nucleus Accumbens and Amygdala Abnormalities in Young Adult Recreational Users

The Journal of Neuroscience, 16 April 2014, 34(16): 5529-5538; doi: 10.1523/JNEUROSCI.4745-13.2014

Marijuana is the most commonly used illicit drug in the United States, but little is known about its effects on the human brain, particularly on reward/aversion regions implicated in addiction, such as the nucleus accumbens and amygdala. Animal studies show structural changes in brain regions such as the nucleus accumbens after exposure to ?9-tetrahydrocannabinol, but less is known about cannabis use and brain morphometry in these regions in humans. We collected high-resolution MRI scans on young adult recreational marijuana users and nonusing controls and conducted three independent analyses of morphometry in these structures: (1) gray matter density using voxel-based morphometry, (2) volume (total brain and regional volumes), and (3) shape (surface morphometry). Gray matter density analyses revealed greater gray matter density in marijuana users than in control participants in the left nucleus accumbens extending to subcallosal cortex, hypothalamus, sublenticular extended amygdala, and left amygdala, even after controlling for age, sex, alcohol use, and cigarette smoking. Trend-level effects were observed for a volume increase in the left nucleus accumbens only. Significant shape differences were detected in the left nucleus accumbens and right amygdala. The left nucleus accumbens showed salient exposure-dependent alterations across all three measures and an altered multimodal relationship across measures in the marijuana group. These data suggest that marijuana exposure, even in young recreational users, is associated with exposure-dependent alterations of the neural matrix of core reward structures and is consistent with animal studies of changes in dendritic arborization.

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